Patients May Receive Too Much Acetaminophen in Hospital

WEDNESDAY, May 23 (HealthDay News) — Roughly 2.5 percent of
admitted hospital patients may receive more than the safe daily cumulative
dose of the pain-reliever acetaminophen, best known as Tylenol, on at
least one day, according to a new U.S. study.

Patients on more than one drug containing acetaminophen often consume
more than the recommended 4 grams per day of the drug, the researchers
from Thomas Jefferson University Hospital in Philadelphia found.

Together, two tablets of extra-strength Tylenol contain 1 gram of
acetaminophen, commonly used to relieve pain and reduce fever.

Over the course of two years, researchers led by Dr. Jesse Civan
examined 46,000 hospital admissions and the medications those patients
were given. They found that on at least one day of hospitalization,
roughly 1,100 patients received more than 4 grams of acetaminophen in the
form of Tylenol, Percocet and similar drugs.

The study authors also assessed the effects the acetaminophen had on
the patients’ livers and found only a small minority were given a blood
test to check their liver function. The investigators noted that this test
is typically used only when a doctor has a specific concern about possible
problems with a patient’s liver.

In the small number of patients who did have the blood test of liver
function, the researchers noted that there were no serious liver injuries.
They said there wasn’t enough information to determine if abnormal test
results were the result of excessive exposure to acetaminophen.

Civan and colleagues concluded that more research is needed to
determine if new recommendations for the safe daily dosing of
acetaminophen are necessary. They added that patients need better
education on acetaminophen safety, particularly for use of the drug after
they leave the hospital, when patients may try to duplicate the
medications and doses they were given during their admission.

The study was presented Monday at the Digestive Disease Week meeting in
San Diego. The data and conclusions should be viewed as preliminary until
published in a peer-reviewed journal.

More information

The U.S. Food and Drug Administration has more about acetaminophen.

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