Post-Charlie Sheen Scientists Find a Way to Edit Out HIV



Susanne.Posel-Headline.News.Official- charlie.sheen.hiv.crispr.edit.virus.temple.university_occupycorporatismSusanne Posel ,Chief Editor Occupy Corporatism | Media Spokesperson, HEALTH MAX Brands

 

After the disaster known as Charlie-gate that brought attention to the need for a viable cure for the HIV virus, it became clear that desperation was setting in.

Researchers from the neuroscience department at Temple University School of Medicine (TUSM) may have found a cure for the AIDS epidemic through the use of the CRISPR gene-editing technique.

This controversial method of removing information from genes and cells has had its critics, including its creators who asked the scientific community not to use CRISPR on human genes.

Jennifer Doundna, co-inventor of the technology and director of the University of California at Berkeley (UCB) Innovative Genomics Initiative (IGI) said : “This limitation has been upended recently by the rapid development and widespread adoption of a simple, inexpensive and remarkably effective genome engineering method known as CRISPR-Cas9. The simplicity of the CRISPR-Cas9 system enables any researcher with knowledge of molecular biology to modify genomes, making feasible many experiments that were previously difficult or impossible to conduct.”

CRISPRs are present in an estimated 40% of sequenced bacteria genomes and 90% of sequenced archaea.

Once the gene is modified, it can be passed down to decedents which is a serious matter when taken into account that research on the human genome is still in its infancy.

The developers of this technique said: “Given the speed with which the genome engineering field is evolving, our group concluded that there is an urgent need for open discussion of the merits and risks of human genome modification by a broad cohort of scientists, clinicians, social scientists, the general public and relevant public entities and interest groups.”

Ignoring that call, TUSM researchers used CRISPR to remove “the memory of the [HIV] virus from the immune system cells that are transformed by the infection. This is how the virus comes back to life after the patient stops taking antiretroviral drugs.

The theory for this study centered on editing the HIV from the cells, therefore eliminating “the viral reservoirs from cells altogether”; effectively inactivating “a large population of… the cells containing the virus.”

This prevents replication of the virus by 90%, according to the study.

Kamel Khalili, lead researcher for the study, explained : “The findings are important on multiple levels. They demonstrate the effectiveness of our gene editing system in eliminating HIV from the DNA of CD4 T-cells and, by introducing mutations into the viral genome, permanently inactivating its replication.

Khalili continued: “”Further, they show that the system can protect cells from reinfection and that the technology is safe for the cells, with no toxic effects.”

Source Article from http://feedproxy.google.com/~r/OccupyCorporatism/~3/MsLM6qyOCfg/

You can leave a response, or trackback from your own site.

Leave a Reply

Powered by WordPress | Designed by: Premium WordPress Themes | Thanks to Themes Gallery, Bromoney and Wordpress Themes