Clot-Busting Drug May Work for Those Who Have Strokes While Asleep

WEDNESDAY, Feb. 1 (HealthDay News) — New research suggests that
it may be safe to give the clot-busting drug tPA to people who wake up
with stroke symptoms, even though there is a short time window in which to
use the treatment and doctors have no idea when these patients first
started experiencing their stroke.

The powerful medication can save lives and stave off lasting disability
after a stroke, but experts believe it needs to be given within 4.5 hours
of the start of symptoms. Almost 25 percent of people who have strokes
have them while they are asleep, the study authors noted, and doctors
typically err on the side of caution, assume the stroke happened when the
patient first went to bed and do not treat with tPA.

However, in this latest study, doctors from King’s College Hospital in
London used a stroke registry to compare 326 patients treated with tPA
within 4.5 hours of symptoms to 68 “wake-up” stroke patients. The second
group only received clot-busting drugs if they had similar symptoms and
showed the same signs of early stroke-related brain changes on CT scans
that people whose strokes occurred within the 4.5-hour window did. The
risks, namely bleeding, of giving tPA outside of this window are thought
to outweigh its benefits.

In the study, the death rates, risk of bleeding inside the brain and
recovery rates after three months were similar in both groups of stroke
patients.

“Our study shows that administering clot-busting drugs to patients with
wake-up stroke who have the same clinical and imaging features as those
treated within current guidelines is feasible and safe,” study author Dr.
Dulka Manawadu, a medical consultant at King’s College Hospital, said in a
news release, although he added that more research is needed to confirm
the findings.

The study was slated to be presented Wednesday at the American Stroke
Association meeting in New Orleans. Research presented at medical meetings
should be viewed as preliminary until published in a peer-reviewed medical
journal.

Of the similar findings between groups,”it is encouraging and it
doesn’t yet prove that they will get the same benefits, but it doesn’t
seem that the risk is excessive,” said Dr. Steven Greenberg, vice chairman
of the International Stroke Conference 2012’s program committee and a
professor of neurology at Harvard Medical School. “Even if only a subset
of wake-up stroke patients were eligible for tPA, it is still a subset of
a substantially large number, so the importance is pretty high.”

The bottom line remains unchanged, he said: “If you or someone you know
is having a stroke, call 911 or get to an emergency room as fast as
possible. The earlier treatment is started within the 4.5-hour window, the
better. With every minute that goes by, you lose part of the benefit and
gain more risk.”

“A large number of patients can’t receive tPA is because they are too
far past the window of opportunity,” added Dr. M. Shazam Hussain, a
neurologist at the Cleveland Clinic, in Ohio. Most “wake-up” strokes do
occur close to when a person wakes up, he noted, so “potentially this will
expand treatment quite significantly.”

“A lot of people are denied treatment because there is no exact time of
onset, because the risks may outweigh the benefits of tPA,” he said. “I
want to see a larger study done, but it certainly lends weight to help
advocate for expanded use of tPA among wake-up stroke patients.”

More information

Find out about stroke warning signs at the American Stroke Association.

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