Searching For Obesity: How Genes Create Our Weight Problems


Susanne.Posel-Headline.News.Official- obesity.bdnf.african.americans.hispanics_occupycorporatismSusanne Posel ,Chief Editor Occupy Corporatism | Co-Founder, Legacy Bio-Naturals
November 2, 2015

 

The National Institutes of Health (NIH) have funded a study on a single variation of the gene that controls brain – derived neurotropic factor (BDNF) which is believed to influence the development of obesity in children and adults.

Understanding BDNF could explain why some people are predisposed to obesity because the gene produces low levels of the BDNF protein – the regulator of appetite in the brain.

This protein plays multiple roles in the brain and nervous system. At elevated levels, BDNF can make a person fell full.

Those with this genetic variation include African Americans and Hispanics; while Caucasians have the variation less frequently.

According to the study : “In African American adults, the C allele was associated with higher BMI and body fat percentage in those with CT or CC types … In the group of Hispanic children, the C allele (CT, CC types) was associated with a higher BMI score.”

The variation discovered in not rare, but a common mutation found among the general population. Because each human has 2 copies of the gene, inheriting one from each parent, the commonness of this issue is staggering.

More than 31,000 male and female participants were broken up into 4 groups. Their BDNF combination were analyzed for factors that would influence obesity such as the person’s body mass index (BMI) or their percentage of body fat.

Jack Yanovski, co – author of the study and investigator with the NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), said: “The BDNF gene has previously been linked to obesity, and scientists have been working for several years to understand how changes in this particular gene may predispose people to obesity. This study explains how a single genetic change in BDNF influences obesity and may affect BDNF protein levels. Finding people with specific causes of obesity may allow us to evaluate effective, more-personalized treatments.”

The researchers used brain tissue samples to determine how even a small change in the gene could lead to the loss of BDNF levels within the hypothalamus – the part of the brain responsible for eating and energy storage.

Joan Han, researcher from the University of Tennessee Health Science Center, explained: “Low BDNF levels may lead to obesity in people. It is important to combat obesity, which has been responsible for many diseases like type-2-diabetes, heart disease, stroke and other disorders.”





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