Electrical Brain Stimulation May Strengthen Memory, Study Says

WEDNESDAY, Feb. 8 (HealthDay News) — Deep brain stimulation, a
technique used to treat Parkinson’s disease and certain psychiatric
disorders, appears to provide some memory-enhancing benefits, researchers
report.

Using electrical impulses to stimulate a part of the brain critical for
memory function significantly improved patients’ navigational ability,
reflecting improved spatial memory, the small study from the University
of California, Los Angeles (UCLA) suggests.

Although the results are still preliminary, the method may potentially
hold promise for boosting memory in patients with early Alzheimer’s
disease, the researchers said.

“The thing to bear in mind is that it’s a first, important step,” said
Suzanne Haber, a brain researcher and professor of pharmacology and
physiology at University of Rochester Medical Center in New York, who
wasn’t involved in the study. “I think it was exciting that they were
really able to show that stimulating that area was important for a certain
kind of learning. It raises more questions, and many more experiments that
can be done.”

Seven patients awaiting possible surgery for the seizure disorder
epilepsy had electrodes implanted in their brains to pinpoint the origin
of their convulsions. The researchers followed them and found they were
better able to recognize landmarks and to navigate routes more quickly in
a video game featuring a taxi cab, virtual passengers and a cyber city.
Patients played the role of cab drivers who picked up passengers and
delivered them to one of six requested shops in the city.

Stimulation of the entorhinal cortex — a region considered crucial to
transforming daily experience into lasting memories — produced the
improvement, the researchers said.

The study is published Feb. 9 in the New England Journal of
Medicine
.

During the video game task, participants learned their way around a
virtual town with and without five-second periods of deep brain
stimulation, and were tested for their ability to reach predetermined
landmarks. Six patients showed a 64 percent reduction in “excess path
length” — the ideal path between destinations, which indicated better
performance — for locations that had been learned during periods of deep
brain stimulation.

For five patients, navigation to each of the three stores learned
during stimulation was faster and shorter than navigation to the three
stores learned without stimulation, indicating a consistent effect, the
study said. Stimulating the hippocampus — a brain region next to the
entorhinal cortex which helps form and store memories — produced no
effect during this experiment, however.

“Critically, it was the stimulation at the gateway into the
hippocampus, and not the hippocampus itself, that proved effective,”
senior study author Dr. Itzhak Fried, a professor of neurosurgery at the
David Geffen School of Medicine at UCLA, said in a university news
release.

“Our preliminary results provide evidence supporting a possible
mechanism for enhancing memory, particularly as people age or suffer from
early dementia. At the same time, we studied a small sample of patients,
so our results should be interpreted with caution,” Fried added.

Currently, deep brain stimulation is used to control the tremors
associated with Parkinson’s, symptoms of obsessive-compulsive disorder and
some other psychiatric conditions, including depression.

Haber noted that the brain damage that occurs with epilepsy, which can
produce memory problems, is different than that resulting from Alzheimer’s
disease, in which the formation of amyloid plaques and neurofibrillary
tangles are believed to contribute to nerve cell deterioration. So it’s
difficult to generalize this study’s results to other diseases that affect
memory, she said, and the research didn’t show if effects of temporary
deep brain stimulation last beyond the study period.

“In these types of studies you think of things like this,” Haber said,
“but how real it is, is something we’re going to have to see. I think just
trying to work out that there is some similarity in very simple learning
[processes in the brain] is important.”

More information

To learn more about deep brain stimulation, visit the American Association of Neurological Surgeons.

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