The protesters gathering in the northwestern city of Bannu on Monday chanted anti-American slogans.
They assembled in a large field to listen to local leaders denounce the US attacks.
In a similar protest on Sunday, thousands of people staged a demonstration in Karachi to condemn the US drone strikes in Pakistan’s northwestern tribal belt.
Over the last three years, the drone strikes have quietly become the US administration’s weapon of choice against suspected militants.
The aerial attacks, initiated by former US President George W. Bush, have escalated under President Barack Obama, who confirmed for the first time last month that the attacks were carried out by the US drones within Pakistan.
The US claims that the drones are used against local militants, but locals say civilians are the main victims.
AGB/HGH