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PFAS Exposure Linked to 56% Percent Higher Risk of Thyroid Cancer

November 5th, 2023

Awake Goy

10/27/23

In the first human data linking per- and polyfluoroalkyl substances (PFAS) to thyroid cancer, a study in The Lancet found higher pre-diagnosis blood levels of perfluorooctanesulfonic acid were associated with 56% greater odds of thyroid cancer diagnosis. Several other PFAS chemicals carried a lower but still increased risk.

By

The New Lede

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By Shannon Kelleher

Exposure to some per- and polyfluoroalkyl substances (PFAS) may increase thyroid cancer risk, according to a study published on Oct. 24.

The analysis, which compared blood samples from 88 people who developed thyroid cancer with samples from people who did not, is the first to document an association between PFAS and thyroid cancer, which had been previously hypothesized.

Past research has linked these endocrine-disrupting chemicals to thyroid disease, a condition in which the gland produces too many or too few hormones.

The new research adds to a growing list of health problems linked to PFAS, including kidney cancer, testicular cancer, ulcerative colitis, high cholesterol and hypertension during pregnancy.

The study, which looked at eight different types of so-called “forever chemicals,” found that doubly high levels of perfluorooctanesulfonic acid (PFOS) in the blood corresponded with a 56% higher risk for thyroid cancer diagnosis.

The PFAS chemicals perfluorononanoic acid (PFNA), perfluorooctylphosphonic acid (PFOPA) and perfluorohexanesulfonic acid (PFHxS) were also found to be associated with thyroid cancer.

“Although preliminary, this is an important study highlighting the risk of thyroid cancer derived from PFAS contamination of water and soil,” said Luca Chiavato, a professor of endocrinology at the University of Pavia in Italy who was not involved with the study.

There are over 12,000 types of PFAS chemicals, which have been used in the manufacturing of many popular consumer goods as well as in industrial processes.

The chemicals do not naturally break down and can leach into drinking water from industrial sites, sewage treatment plants, landfills or certain firefighting foams.

A 2022 analysis found detectable PFAS levels in about 83% of U.S. waterways, with concerns about the widespread contamination leading the U.S. Environmental Protection Agency (EPA) to propose national drinking water standards for six types of PFAS last spring.

The chemical giants 3M, DuPont and others agreed to settlements over the summer to provide affected communities with billions of dollars to test for the toxic chemicals and remove them from their drinking water.

Water utilities across the country will decide in the next three months whether to join the settlements. Meanwhile, Connecticut residents recently filed a class action lawsuit against two of the state’s water suppliers over PFAS in their drinking water, while PFAS producers are challenging a class action suit in Ohio that could include as many as 11.8 million residents.

The EPA announced on Oct. 20 that it has closed a loophole that allowed the industry to get out of reporting small amounts of PFAS released during manufacturing, mining and other activities.

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Driving thyroid cancer?

Thyroid cancer diagnoses worldwide have risen sharply in recent years, with a 20% increase from 1990 to 2013. But while scientists have previously suspected that PFAS exposure is contributing to the trend, there has been a lack of studies in human populations.

“The uniqueness of the study we did is that we were able to use these blood samples that were taken before the participants of this biorepository we have at Mount Sinai Hospital were diagnosed with cancer,” said Maaike van Gerwen, a director of research in the New York-based hospital’s department of otolaryngology.

Van Gerwen and colleagues matched blood samples from 88 people who were later diagnosed with thyroid cancer to samples from healthy people, which were matched for age, sex, body mass index, race and, when possible, whether or not they smoked.

The researchers also performed a separate analysis with samples from 31 people who had their blood samples taken at least a year before they were diagnosed with cancer, allowing them to better account for the time between when the participants were exposed to PFAS and when they developed cancer, said van Gerwen.

“We were limited to the number of thyroid cancer patients in [the biobank],” she said. “It’s a relatively small study. In the paper, we definitely recommend redoing this work with a larger population.”

While perfluorooctanoic acid (PFOA) is the only PFAS chemical classified as “possibly carcinogenic to humans” by the International Agency for Research on Cancer, it was not found to be significantly associated with thyroid cancer within the new study, said van Gerwen.

“That’s definitely something to reevaluate,” she said. Van Gerwen added that she would also be interested in learning if some of the more recently introduced PFAS chemicals are associated with thyroid cancer, which she said would require a larger sample size.

Next, van Gerwen and colleagues plan to replicate their study using a bigger, Europe-wide collection of blood samples from thyroid cancer patients. The researchers also hope to collaborate with Veterans Affairs hospitals to study links between PFAS exposure and thyroid cancer in military personnel.

More than 700 military sites around the U.S. may be contaminated with the toxic chemicals, putting service members and their families at elevated risk.

Originally published by The New Lede.

Shannon Kelleher is a staff reporter for The New Lede.

PFAS Exposure Linked to 56% Percent Higher Risk of Thyroid Cancer

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If you are a doctor or medical professional and you are reading this and aware of what is happening, the time for you to stay silent on account of self-preservation is over. The weight of what you know vs. a license, a job, etc., is too great. “Just following orders” or fear of scrutiny won’t cut it anymore. Several have come before you to lay the groundwork so you, too, can be brave.

If you are the every-man, there are still people you haven’t spoken to. Call them today. Don’t wait. Prepare your information, and get it ready for an email or text. Sit with them and discuss it. Have them over. Watch an interview or seminar. Make them stay out of respect for you because you are respecting them; you are trying to save their life.

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The third step is to unsubscribe from all mainstream media outlets. Delete the apps from your phone, laptop, and tablet and unfollow all of their social media and YouTube channels. Try to avoid mainstream media for at least one week, even if the headline is intriguing.

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The fourth step of the global walkout is to move as many accounts as you can to a union or local bank.

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