Aspirin, Warfarin Fare Equally for Heart Failure Patients

FRIDAY, Feb. 3 (HealthDay News) — A major head-to-head trial
finds that aspirin is equally as good as warfarin in preventing stroke and
death in heart failure patients.

The researchers said that, all things being equal, the findings raise
questions about the wisdom of routinely using warfarin (Coumadin), which
can cause dangerous bleeding. The findings were presented Friday at the
annual meeting of the American Stroke Association in New Orleans.

Heart failure patients are at increased risk for blood clots, stroke
and death.

The study is the largest and longest of its kind to date and included
more than 2,300 patients averaging 61 years of age. All patients had
heart failure and a normal heart rhythm, and were followed for up to six
years (average 3.5 years).

The patients were randomly assigned to receive either 325 milligrams a
day of aspirin or warfarin doses meant to achieve a pre-specified degree
of blood thinning.

Death, ischemic stroke (caused by blockage of an artery carrying blood
to the brain) or bleeding inside the brain (intracerebral hemorrhage)
occurred in about 8 percent of the patients taking aspirin and about 7.5
percent of those taking warfarin. This difference was not deemed to be
statistically significant, the research team said.

Among patients who were followed for more than three years, strokes
occurred in 0.72 percent of those taking warfarin and in 1.36 percent of
those taking aspirin, according to the study. While warfarin users had
half the stroke risk of those on aspirin, the overall risk for stroke for
patients in either group was considered low.

On the other hand, the researchers found that major bleeding (other
than intracerebral hemorrhage) occurred in 0.9 percent of the patients on
aspirin each year, compared with 1.8 percent of those on warfarin. That
was a statistically significant difference, the team said.

“Although there was a warfarin benefit for patients treated for four or
more years, overall, warfarin and aspirin were similar,” lead author Dr.
Shunichi Homma, a professor of medicine at Columbia University in New York
City, said in a stroke association news release.

“Given that there is no overall difference between the two treatments
and that possible benefit of warfarin does not start until after four
years of treatment, there is no compelling reason to use warfarin,
especially considering the bleeding risk,” Homma noted.

One expert said the study provides valuable information to doctors and
patients.

“There has always been a question about whether warfarin or aspirin is
better when treating heart failure in patients with normal heart rhythms,
so this is a very important study,” noted Dr. Kenneth Ong, a cardiologist
at The Brooklyn Hospital Center in New York City.

“Until now, we considered warfarin a more potent anti-clotting drug
than aspirin, though each affects a different mechanism of clotting,” he
explained. “In the past, the only reason to put heart failure patients on
warfarin was in the case of patients with a history of strokes, transient
ischemic strokes (TIA or ‘mini-stroke’) or an irregular heart rhythm.
This study confirms current standards of treatment. Aspirin is just as
effective as warfarin in the treatment of heart failure, but warfarin is
indicated for high-risk patients.”

Homma’s team said that they are currently analyzing whether certain
subgroups of patients benefited more from either aspirin or warfarin.

Because this study was presented at a medical meeting, the data and
conclusions should be viewed as preliminary until published in a
peer-reviewed journal.

More information

The U.S. Agency for Healthcare Research and Quality has more about blood
thinners
.

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