Experimental Drug Suppresses Appetite in Mice: Study

THURSDAY, July 26 (HealthDay News) — An experimental drug tested in
mice might one day help people lose weight and keep it off long-term,
according to researchers.

The drug, called JD5037, increases sensitivity to the hormone leptin, a
natural appetite suppressant found in the body, according to a study in
the July 26 issue of the journal Cell Metabolism.

“By sensitizing the body to naturally occurring leptin, the new drug
could not only promote weight loss, but also help maintain it,” senior
study author George Kunos, of the U.S. National Institute on Alcohol Abuse
and Alcoholism, said in a journal news release. “This finding bodes well
for the development of a new class of compounds for the treatment of
obesity and its metabolic consequences.”

Leptin supplements alone are not effective at helping people lose
excess weight, according to the release. It’s believed that this is due to
desensitization to leptin, which means that the body can no longer respond
to leptin.

In this study, the researchers found that JD5037 suppressed the
appetite of obese mice and led to weight loss, in part by resensitizing
the mice to leptin.

Scientists note, however, that research with animals often fails to
provide similar results in humans.

“Obesity is a growing public health problem, and there is a strong need
for new types of medications to treat obesity and its serious metabolic
complications, including diabetes and fatty liver disease,” Kunos
said.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney
Diseases offers tips on safe and effective weight-loss programs.

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