Simple blood test set to revolutionise cancer care by showing whether treatment

By
Tamara Cohen

13:23 EST, 30 May 2012

|

01:43 EST, 31 May 2012

A simple blood test could revolutionise cancer care by showing patients whether their treatment is working, scientists say.

British researchers have devised a way of closely monitoring the progress of tumours without the need for surgery  or scans.

In a world first, they used blood analysis to detect deadly mutations in 20 of 38 patients studied with breast and ovarian cancer.

A man performs a blood test on himself, which could soon be the simplest way to check on whether your cancer treatment is working

A man performs a blood test on himself, which could soon be the simplest way to check on whether your cancer treatment is working

They even managed to build up a picture of how one woman’s breast cancer responded to different treatments over 16 months.

The researchers say the blood test,
which could potentially  save thousands of lives, could  be available to
patients within  five years.

Currently those with cancer often need to have tissue samples surgically removed for analysis.

The new test uses sequencing – a
technique to read genetic code – to look for tiny pieces of DNA that
cancer tumours shed into the bloodstream and are not picked up by
current screening methods.

This could alert doctors when a
treatment is not working, allowing them to try alternatives, as well as
potentially sparing the patient unnecessary side effects.

Blood samples were taken from women either before, during or after chemotherapy at Addenbrooke’s Hospital in Cambridge.

Dr Nitzan Rosenfeld, who led the study
at the Cancer Research UK Cambridge Research Institute, said: ‘This
type of blood test has the potential to revolutionise the way we
diagnose and treat cancer.

‘The great advantage is that it can be
used to identify cancer mutations without surgery or a biopsy, making
it safer and cheaper.’

DNA sequencing is widely used by
scientists, but Dr Rosenfeld’s team found a way to home in on key genes
known to be ‘cancer hot spots’ and analyse them in detail.

This is the first time entire genes
have been analysed from a blood test, which enabled the researchers to
examine 20,000 possible mutations in six cancer-related genes.

The DNA double helix: Dr Rosenfeld's team found a way to home in on a few key genes known to be 'cancer hospots' and analyse them in detail

The DNA double helix: Dr Rosenfeld’s team found a way to home in on a few key genes known to be ‘cancer hospots’ and analyse them in detail

Using a
blood sample from a 56-year-old woman with breast cancer, they were able
to see in retrospect that the first type of treatment she was given had
not worked.

Dr Rosenfeld said: ‘We could see in a
blood test what the doctors could only see using extensive imaging. It
suggests that if we had looked at a different time point, we may have
been able to spot it earlier.

‘Doctors could try different types of
chemotherapy or refer patients to a specific clinical trial. It broadens
the scope for more personalised medicine.’ He said more tests would be
needed to see which other cancers could be detected using the same
process, but there was no reason why it would not work if scientists
targeted the right gene.

Their study is published today in the journal Science Translational Medicine.

Co-author Dr James Brenton, an ovarian
cancer clinician, said: ‘I think these results are very exciting
because work from us and  others really says now that blood could be an
important way of  measuring response and finding these mutations.

‘It offers us an opportunity to follow
the disease in real time as it changes, helping us to respond and
change the treatments we use.’

 

Here’s what other readers have said. Why not add your thoughts,
or debate this issue live on our message boards.

The comments below have not been moderated.

this is why i read the british daily mail. great articles like this, it will be days perhaps even weeks before this story is published in an american newspaper, many great stories in fact never reach the american public thru american media, thank you

Good news, too late for me but hopefully it will help my children.

Everything seems to be 5 to 10 years way with all these breakthroughs which must be very disheartening to those that need the treatment now.

So if you do not die through the medication you cannot afford, or have the wrong post-code, well a good chance the surgeons will have been imported from Germany, and do not know what a metric system – problem solved, no need for medication as the placebo’s that cost 3p an hundred are not working.
Me a cynic?.
Yes!

The views expressed in the contents above are those of our users and do not necessarily reflect the views of MailOnline.

You can skip to the end and leave a response. Pinging is currently not allowed.

Leave a Reply

Powered by WordPress | Designed by: Premium WordPress Themes | Thanks to Themes Gallery, Bromoney and Wordpress Themes