Booster: the immune system is so disturbed that autoimmune reactions are triggered.

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Booster: the immune system is so disturbed that autoimmune reactions are triggered.

December 15th, 2021

Awake Goy

An important study from 2009. Very relevant to assess the consequences of the booster vaccinations currently being carried out. At some point, the immune system is so disturbed that autoimmune reactions are triggered.

Definition of Autoimmunity: involves a misdirection of the body’s immune system against its own tissues

Repeated vaccinations with the same antigen at short intervals (“booster shots”) destabilise the immune system so that autoimmune processes occur. Among other things, antibodies against one’s own DNA can be formed, as this work showed:

Abstract

Background

The cause of autoimmunity, which is unknown, is investigated from a different angle, i.e., the defect in immune ‘system’, to explain the cause of autoimmunity.

Methodology/Principal Findings

Repeated immunization with antigen causes systemic autoimmunity in mice otherwise not prone to spontaneous autoimmune diseases. Overstimulation of CD4⁺ T cells led to the development of autoantibody-inducing CD4⁺ T (aiCD4⁺ T) cell which had undergone T cell receptor (TCR) revision and was capable of inducing autoantibodies. The aiCD4⁺ T cell was induced by de novo TCR revision but not by cross-reaction, and subsequently overstimulated CD8⁺ T cells, driving them to become antigen-specific cytotoxic T lymphocytes (CTL). These CTLs could be further matured by antigen cross-presentation, after which they caused autoimmune tissue injury akin to systemic lupus erythematosus (SLE).

Conclusions/Significance

Systemic autoimmunity appears to be the inevitable consequence of over-stimulating the host’s immune ‘system’ by repeated immunization with antigen, to the levels that surpass system’s self-organized criticality.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008382