Brain EEG Test Might Help Spot Autism: Study

TUESDAY, June 26 (HealthDay News) — Electroencephalogram (EEG),
a test that shows the electrical activity of the brain, might be used to
spot autism in children, a new study suggests.

The study, conducted by researchers at Harvard University Medical
School, looked at the synchronization of brain activity across different
brain regions, as measured by EEG.

“These scientists used sensors to record electrical brain activity
across many different regions on the scalp,” explained Geraldine Dawson,
chief science officer at the advocacy group Autism Speaks. “They then
looked at the extent to which brain activity from one region was
synchronized with brain activity from another region,” a phenomenon known
as “EEG coherence,” said Dawson, who was not involved in the research.

“Synchronization between different brain regions indicates that those
regions are functioning in a coordinated, rather than independent,
fashion — in other words, they are functionally connected and
communicating with each other,” she said.

In the new study, Dr. Frank Duffy and Dr. Heidelise Als compared EEG
measurements of nearly 1,000 children with and without autism. They found
that the two groups had widespread differences in terms of brain
connectivity.

EEG revealed that the children with autism had a reduced short range
connectivity, indicating poor function of local brain networks. This was
especially true in the left hemisphere regions of the brain responsible
for language.

The children with autism also had increased connectivity between brain
regions that were farther apart, which might be a mechanism developed to
compensate for reduced short range connectivity, the researchers said.

The research was conducted at Boston Children’s Hospital and was
published online June 25 in the journal BMC Medicine.

The use of EEG-based testing may help diagnose autism in children and
may improve early detection in infants, leading to more effective
treatments and coping strategies, the researchers said.

“What was unique about this study is the very large number of children
studied,” Dawson noted. “Consistent with many previous studies using EEG
and functional MRI with both children and adults with autism, these
investigators found that, overall, children with autism show reduced
coordination (coherence) across brain regions.”

She said the findings are important because, “they help us understand
why individuals with autism have difficulty with complex behaviors, such
as social interaction and language. As children’s brains develop, the
different brain regions become increasingly connected, allowing for the
acquisition of complex behaviors that require coordination across
different brain regions.”

Language, for example, requires coordination across the auditory,
visual, and motor brain regions, as well as the participation of the
prefrontal cortex, she said.

“This reduced functional connectivity in the brain helps us understand
impairments associated with autism,” she added. “The hope is that early
behavioral intervention can help mitigate these functional impairments,
helping to form the connections that natural develop in typical
children.”

Another expert agreed.

“Although autism is still principally a clinical diagnosis, this study
.. may allow for a new approach to classifying children with autism and
may even assist in the early identification of affected children at a
younger age,” said Dr. Andrew Adesman, chief of developmental and
behavioral pediatrics at the Steven Alexandra Cohen Children’s
Medical Center of New York in New Hyde Park, NY.

The number of children diagnosed with autism in the United States has
recently increased to one in 88.

More information

The U.S. National Institute of Neurological Disorders and Stroke has
more about autism.

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