Research Sheds Light on Gene Mutation’s Role in Rare Tumors

WEDNESDAY, Dec. 21 (HealthDay News) — Mutations in a gene called
DICER are associated with rare, seemingly unrelated ovarian, uterine and
testicular cancers, a new study finds.

The Canadian researchers said they were surprised to discover that the
same fundamental mutation in the DICER gene was the common process
underlying all these different cancers.

The study was published in the Dec. 21 issue of the New England
Journal of Medicine
.

“DICER is of great interest to cancer researchers,” team leader Dr.
David Huntsman, a genetic pathologist and director of the Ovarian Cancer
Program of B.C. at the British Columbia Cancer Agency and Vancouver
Coastal Health Research Institute, said in a University of British
Columbia news release.

“There have been nearly 1,300 published studies about it in the last 10
years, but until now, it has not been known how the gene functions in
relation to cancer,” said Hunstman, who is also a professor in the
departments of obstetrics and gynecology, and pathology and laboratory
medicine at UBC.

This new finding could lead to breakthroughs for treatments of more
common cancers, according to the researchers.

“Studying rare tumors not only is important for the patients and
families who suffer from them but also provides unique opportunities to
make discoveries critical to more common cancers — both in terms of
personalized medicine, but also in applying what we learn from how we
manage rare diseases to more common and prevalent cancers,” Huntsman
explained.

“The discovery of the DICER mutation in this varied group of rare
tumors is the equivalent of finding not the needle in the haystack, but
rather the same needle in many haystacks,” he added.

More information

The U.S. National Cancer Institute has more about cancer research.

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