Story at-a-glance
- Significant concerns have been raised surrounding antibody‐dependent enhancement (ADE), and the possibility that COVID-19 vaccines could worsen COVID-19 disease via ADE
- International Journal of Clinical Practice researchers called the risk of ADE in COVID-19 vaccines not only nontheoretical but also compelling
- They noted that vaccine-elicited enhancement of disease has been previously found with SARS and Middle East respiratory syndrome-related (MERs) coronaviruses, as well as feline coronavirus, all of which are closely related to SARS-CoV-2, which causes COVID-19
- Given the strong evidence of ADE risk from COVID-19 vaccines, the researchers believe that a separate informed consent form should be given out to those receiving the vaccine, warning them of the specific risk of worsened COVID-19 disease from vaccination
- Despite researchers recommending back in October 2020 that ADE risk be “prominently and independently disclosed” to patients, no such warning exists
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