Can Testosterone Therapy Help Obese Men Lose Weight?

WEDNESDAY, May 9 (HealthDay News) — Older obese men with low
levels of testosterone can lose weight when levels of the male hormone are
restored to normal, a new study suggests.

But it might not be the testosterone itself. Rather, it could be that
men undergoing the hormone therapy feel better and stronger so they
exercise more and watch their diet, speculated experts not involved with
the study.

“It [the study’s conclusion] is overly optimistic,” said Dr. Bradley
Anawalt, a spokesman for The Endocrine Society and chief of medicine at
the University of Washington Medical Center in Seattle. “There is very
little evidence that testosterone should cause weight loss in men obese or
otherwise; it usually results in weight gain.”

Anawalt, who was not involved in the study, noted the study was
sponsored by Bayer, which makes testosterone supplements.

“If you were a drug company, the best product in the world would be a
drug that causes you to lose weight, increases muscle and strength and
improves your sex drive,” he said.

Testosterone shouldn’t be looked at as a miracle weight-loss drug,
Anawalt said. “Before anybody got excited about this, there [would] need
to be lot more studies done to reproduce these findings,” he added.

The findings were to be presented Tuesday at the European Congress on
Obesity in Lyon, France.

The study was led by Dr. Farid Saad, from Bayer Pharma AG in
Berlin.

For the study, the researchers followed 251 obese men aged 38 to 83
with low testosterone levels. Among these men, 214 were followed for two
years and 115 were followed for five years.

The men were given 1,000 milligrams of testosterone by injection when
the study started, again at six weeks and then every 12 weeks until the
end of the trial.

The men who were followed for five years lost an average of 35 pounds.
Their average body-mass index — a measurement that takes height and
weight into account — dropped from 34 to 29, moving them from the obese
category into the overweight category. In addition, they also saw
improvements in their cholesterol and triglyceride levels, along with
their blood pressure.

In addition, there was no increase in the risk of prostate cancer,
researchers noted.

“Raising serum testosterone to normal reduced body weight, waist
circumference and blood pressure, and improved metabolic profiles. These
improvements were progressive over the full five years of the study,” the
study authors said.

Obesity has been linked with reduced testosterone, according to the
researchers. Men older than 45 who have low testosterone levels are about
twice as likely to be obese, have type 2 diabetes and have high blood
pressure as men with normal testosterone levels, they added.

There may be a number of reasons why, the study authors said. Increased
testosterone improves energy and motivation to do physical activity;
testosterone also increases lean body mass, which increases the amount of
energy used.

Another expert, Dr. Spyros Mezitis, an endocrinologist at Lenox Hill
Hospital in New York City, added that “anecdotally we have been seeing
improvement in elderly men with low testosterone taking testosterone,
including improved cholesterol, more lean body mass and fat loss.”

Mezitis agreed that the weight loss may have been a result of feeling
better and stronger, allowing the men to exercise more.

Because this study was presented at a medical meeting, the data and
conclusions should be viewed as preliminary until published in a
peer-reviewed journal.

More information

For more on obesity, visit the U.S.
National Library of Medicine
.

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