Ibuprofen May Ward Off Altitude Sickness

TUESDAY, March 20 (HealthDay News) — The anti-inflammatory and
painkiller ibuprofen seems to reduce the risk of altitude sickness,
according to a new study.

Headache, fatigue, nausea, dizziness, vomiting and poor appetite are
among the symptoms of altitude sickness, which affects more than 25
percent of Americans who travel to high elevations each year to ski, hike
or camp.

If unrecognized or untreated, altitude sickness can lead to
high-altitude cerebral edema, a potentially fatal swelling of the
brain.

The Stanford University study, which included 58 men and 28 women, was
conducted in California’s White Mountains. The participants spent the
first night at 4,100 feet altitude. The following morning, they were given
either 600 milligrams of ibuprofen or a placebo before hiking up the
mountain to a staging area at 11,700 feet. After receiving a second dose
at 2 p.m., the participants continued their hike to 12,570 feet, where
they received a third dose at 8 p.m. before spending the night on the
mountain.

Symptoms of altitude sickness developed in 19 participants who received
ibuprofen (43 percent) and 29 of those who received the placebo (69
percent), indicating ibuprofen reduced the incidence of altitude sickness
by 26 percent.

Among the participants who developed altitude sickness, those who took
ibuprofen had less severe symptoms than those who took the placebo, though
it was not statistically significant.

The study appears online March 20 in the Annals of Emergency
Medicine
.

“Ibuprofen could be a way to prevent [altitude sickness] in a
significant number of the tens of millions of people who travel to high
altitudes each year,” lead author Dr. Grant Lipman, an emergency-medicine
physician at Stanford Hospital Clinics and a clinical assistant
professor at the Stanford University School of Medicine in Stanford,
Calif., said in a university news release.

Ibuprofen is a widely available over-the-counter drug that is safer and
causes fewer side effects than two medications (acetazolamide and
dexamethasone) currently used to prevent altitude sickness, the
researchers noted.

More information

There is more about altitude sickness at altitude.org.

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