Travel to High Altitudes Tied to Crohn’s, Colitis Flare-Ups

FRIDAY, May 25 (HealthDay News) — People with inflammatory bowel
disease, which includes Crohn’s disease and colitis, may be at increased
risk for flare-ups when they fly or travel to high altitudes for skiing or
mountain climbing, a new study suggests.

This complications affected patients with either Crohn’s disease (which
typically involves the small intestine) or ulcerative colitis (which
typically involves the large intestine and rectum), but the risk appears
to be higher in those with Crohn’s disease, the researchers found.

The study included 103 patients who were seen at inflammatory bowel
disease clinics in Switzerland. The 52 patients with flares and the 51
patients who were in remission were asked about their activities during
the previous month.

Overall, patients with flares had made many more frequent flights or
trips to areas above 6,500 feet.

The study was to be presented Monday at the Digestive Disease Week
meeting in San Diego.

In high altitudes, lower oxygen content in the air means that people
may not get all the oxygen their bodies are used to getting. People who
live at lower altitudes may experience headaches, weakness and other
symptoms until they acclimate to the lower oxygen content in the air.

How that might connect to inflammatory bowel disease is unknown,
according to researchers. Oxygen depletion in any tissue (hypoxia) causes
inflammation, but there are little available data about how hypoxia might
exacerbate inflammatory bowel disease, said study author Stephan Vavricka,
chief of the gastroenterology and hepatology division at Trieml Hospital
in Zurich.

“We need to look more closely at how hypoxia may induce inflammation on
a molecular level in the intestines,” he said in a meeting news
release.

The study was too small to draw conclusions about inflammatory bowel
disease symptoms or severity based on whether a patient had been flying,
skiing, hiking, climbing or just visiting high-altitude locations.

“It’s too early to tell patients not to get on a plane or to restrict
where they go,” said Vavricka, who plans further research with a larger
number of patients.

Because this study was presented at a medical meeting, the data and
conclusions should be viewed as preliminary until published in a
peer-reviewed journal.

More information

The U.S. Office on Women’s Health has more about inflammatory bowel disease.

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