TUESDAY, May 29 (HealthDay News) — Should the lungs of smokers
be included in lung transplants? A new study suggests their inclusion may
be warranted.
The study found that lung transplant patients who receive smokers’
lungs still are more likely to survive than those who refuse such lungs
and remain on the transplant waiting list.
The lives of patients who receive smokers’ lungs, however, tended to be
shorter than those who receive the lungs of non-smokers, the British
researchers added. Given the evidence, however, Britain’s policy of using
smokers’ lungs for transplant should be continued, according to the
authors of the study published online May 28 in The Lancet.
The issue is not just a British one — speaking to the Associated
Press, Dr. Normam Edelman, chief medical officer for the American Lung
Association, said smokers’ lungs are also used for transplant in the
United States, although he did not have data on how common the practice
might be.
But the bottom line from the new study is that “patients awaiting lung
transplantation in the U.K. are likely to survive longer if they are
willing to accept lungs from any suitable donor, irrespective of smoking
history,” lead author Dr. Robert Bonser, of the Queen Elizabeth Hospital
in Birmingham and the University of Birmingham, said in a journal news
release. “Donors with a positive smoking history provide nearly 40 percent
of the lungs available for transplantation [in the U.K.] Rejection of this
donor-organ resource would increase waiting-list mortality and is
ill-advised.”
Bonser and his colleagues examined the survival rates for nearly 2,200
adult patients in the United Kingdom awaiting lung transplants between
1999 and 2010. Of the nearly 1,300 lung transplants that took place during
that time, about two in every five came from donors with a history of
smoking.
Patients who received smokers’ lungs were 46 percent more likely to
have died three years after transplantation than those who received lungs
from non-smokers. However, patients who received smokers’ lungs also were
21 percent less likely to die than those who remained on the waiting
list.
The researchers also found that including smokers’ lungs in the donor
pool increased the likelihood of survival by 61 percent for patients with
fibrosis and by 40 percent for those with septic lung disease.
“Although lungs from such donors are associated with worse outcomes,
the individual probability of survival is greater if they are accepted
than if they are declined and the patient chooses to wait for a potential
transplant from a donor with a negative smoking history,” the authors
wrote. “This situation should be fully explained to and discussed with
patients who are accepted for lung transplantation.”
One expert in the United States said the study “raises a few
issues.”
Dr. Len Horovitz, pulmonary specialist at Lenox Hill Hospital in New
York City, said that “because many patients may die awaiting transplant,
one might argue that a lung damaged by smoking (not severely) would be
better than no functioning lung at all. But lungs of smokers may be mild
or moderately damaged (COPD), and also carry the risk of lung cancer,
especially with post operative chronic use of immune suppressors.
Nevertheless, in a dying patient, the prolongation of life — however long
that may be — [and] the benefit is clear.”
Although these findings have clear implications for the United Kingdom,
it “is important to realize that the relation between risk of dying on the
waiting list and the benefit of accepting a transplant from a donor with a
substantial smoking history can vary by country and center,” Dr. Shaf
Keshavjee and Dr. Marcelo Cypel of the Toronto Lung Transplant Program of
the University Health Network in Canada, wrote in an accompanying
commentary in the journal.
More information
The U.S. National Heart, Lung, and Blood Institute has more about lung transplantation.
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