Bariatric Surgery Changes Metabolism and Genes

MedPage Today – Weight loss following gastric bypass surgery was associated with changes in gene methylation that may affect insulin sensitivity, researchers said. Whereas expression of 14 genes was abnormal prior to surgery because of different levels of DNA promoter methylation, compared with normal-weight patients, methylation status at 11 of the genes was normalized in the surgical patients when analyzed after weight loss had occurred, according to Juleen R. Zierath, PhD, of the Karolinska Institute in Stockholm. Read article

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