Healthy Weight Loss May Also Cut Your Cancer Risk

TUESDAY, May 1 (HealthDay News) — Moderate weight loss reduces levels
of inflammation that have been tied to certain cancers, at least in
postmenopausal women, a new study suggests.

According to the findings, older women who lost at least 5 percent of
their body weight through diet alone or diet plus exercise showed
significant reductions in key inflammatory blood markers such as
C-reactive protein and interleukin-6.

In addition to risk for heart disease, elevated levels of these markers
have also been associated with increased risk for several cancers,
including breast, colon, lung and endometrial cancer.

The findings appear May 1 in the journal Cancer Research.

“Our findings support weight loss through calorie reduction and
increased exercise as a means for reducing inflammatory biomarkers and
thereby potentially reducing cancer risk in overweight and obese
postmenopausal women,” said researchers led by Dr. Anne McTiernan,
director of the Prevention Center at the Fred Hutchinson Cancer Research
Center, in Seattle.

Aiming to lose 10 percent of their body weight, the women were either
placed on a calorie-restricted diet, asked to participate in moderate-to
vigorous-aerobic exercise for 45 minutes a day for five days a week, or
told to do both.

During the one-year study, C-reactive protein levels went down by about
36 percent in the diet-alone group and by 42 percent in the diet and
exercise group. Interleukin-6 levels decreased by about 23 percent in the
diet group and 24 percent in the diet and exercise group, the study
showed. There were greater reductions in these levels seen among women
who lost at least 5 percent of their body weight. Exercise alone did not
affect levels of inflammation markers.

There was no information on which, if any, of the 438 women in the
study went on to develop cancer. But a 40 percent reduction in C-reactive
protein “could be expected to reduce breast, endometrial and other cancer
risk in postmenopausal women,” the study authors said.

Dr. Louis Aronne, founder and director of the Comprehensive Weight
Control Program at New York-Presbyterian Hospital/Weill Cornell Medical
Center, in New York City, said: “This adds to the body of evidence showing
that with small weight loss, fat cells shrink and inflammatory hormones go
down. There are many things besides coronary disease that depend on
inflammation.”

Dr. Mitchell Roslin, chief of obesity surgery at Lenox Hill Hospital in
New York City, agreed. “Obesity induces a chronic state of inflammation
that may also be the cause of metabolic diseases like type 2 diabetes and
certain cancers,” he said. “Obesity is driving this inflammatory state,
and when we reverse it, we also reverse the process that causes some
cancers and diabetes.”

More information

Learn about the health benefits of moderate weight loss at the U.S.
Centers for Disease Control and Prevention.

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