US officials have asked labs to submit plans for ramping up production of the experimental Ebola drug, Zmapp, of which supplies have run out. It successfully treated medical workers infected with the virus, but hasn’t been widely tested for safety.
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The US Department of Health and Human Services, through its BARDA
division, issued the order for mass producing the antiviral
cocktail on Thursday. Three advanced biological laboratories have
until November 10 to submit detailed plans with budgets and
timetables, according to Reuters.
The US government “is working with partners around the world
as quickly as possible to advance the development of multiple
vaccine and therapeutic candidates for clinical evaluation and
future use in preventing or treating Ebola,” BARDA Director
Robin Robinson said in a statement.
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Efforts to boost ZMapp production capacity are underway at the
Centers for Innovation in Advanced Development and Manufacturing,
which is composed of three separate labs: the Texas A&M
Health Science Center in partnership with Britain’s
GlaxoSmithKline Plc, Emergent Biosolutions in Maryland, and
Novartis AG lab in North Carolina.
The three advanced labs were established by the US government in
2012 with $440 million in seed money, and are required to develop
flexible manufacturing capabilities to allow them to produce
countermeasures against chemical, biological, and other threats.
❗️US Army part owner of #EbolaMed
=> #ZMapp dev by
Mapp Biopharmaceutical of San Diego. Given to Dr Brantley
http://t.co/MlFlSqq3IU
— Mary Mauldin (@marymauldin) October
18, 2014
READ MORE: Liberia to get experimental Ebola drug as death toll
tops 1,000
Supplies of ZMapp, which was manufactured by San Diego-based Mapp
Pharmaceuticals, ran out in August after it was given to two
American medical workers who contracted the disease in Liberia –
Dr. Kent Brantly and Nancy Writebol. Both of the workers
recovered. The drug is a cocktail of antibodies engineered to
recognize the virus and bind to infected cells, and is made from
genetically modified tobacco plants.
It is Time All World Leaders demanded Full Open sourcing of the
ZMAPP Drug and committed funds to contain Ebola. This is a very
severe Risk
— Sidharth (@i_sidh) October
15, 2014
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“We look forward to leveraging our manufacturing capabilities
to expand production of this experimental therapeutic and to find
other ways to support the U.S. government’s fight against
Ebola,” said Adam Havey, president of Emergent’s biodefense
division. He also told Reuters that the company has been in
discussions with plant-based manufacturers to develop a response
to the task order.
It must be noted, however, that according to the Centers for
Disease Control and Prevention (CDC), ZMapp has yet to be tested
for safety and effectiveness in humans. Also,
ZMapp can’t prevent infection, as it’s a therapeutic drug, not a
vaccine for Ebola.
Source Article from http://rt.com/usa/197048-ebola-drug-zmapp-ramp-up/
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