The incident occurred on Thursday when US unmanned aircraft fired a rocket at a convoy of vehicles in the Shibam area of the Hadhramaut region, Reuters quoted a Yemeni security official as saying.
There has recently been a rise in the US assassination drone strikes in Yemen.
The locals say the main victims of the aerial bombardments have been civilians.
One of the deadliest US air raids took place in 2009, when dozens of people, many of them women and children, were killed in US raids.
The strikes have given rise to anti-US sentiments in the impoverished Arab nation, where many discredit President Abd-Rabbu Mansour Hadi as a puppet of Washington.
Hadi took power with direct support from the United Stated and Saudi Arabia in a one-man presidential race held after the eventual resignation of dictator Ali Abdullah Saleh in February.
MRS/HJL/IS
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